|Application ||WB, IHC-P, E|
|Other Accession||NP_001171525.1, NP_037383.1|
|Calculated MW||13438 Da|
|Antigen Region||54-83 aa|
|Other Names||Tachykinin-3, ZNEUROK1, Neurokinin-B, NKB, Neuromedin-K, TAC3, NKNB|
|Target/Specificity||This TAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the Central region of human TAC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.
Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010) :
Hrabovszky, E., et al. Eur. J. Neurosci. 31(11):1984-1998(2010)
Gianetti, E., et al. J. Clin. Endocrinol. Metab. 95(6):2857-2867(2010)
Young, J., et al. J. Clin. Endocrinol. Metab. 95(5):2287-2295(2010)
Semple, R.K., et al. Front Horm Res 39, 133-141 (2010) :
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