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MAGOH Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAGOH Antibody (Center) AP14367c
    MAGOH Antibody (Center) (Cat. #AP14367c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MAGOH antibody detected the MAGOH protein (arrow).
  • IHC-P - MAGOH Antibody (Center) AP14367c
    MAGOH Antibody (Center) (AP14367c)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MAGOH Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61326
Other Accession Q27W02, P61327, Q566Y8, P50594, Q3ZBV3, Q9CQL1, Q96A72, Q0VC92, NP_002361.1
Reactivity Human
Predicted Bovine, Mouse, Chicken, Zebrafish, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 17164 Da
Antigen Region 46-74 aa
Additional Information
Gene ID 4116
Other Names Protein mago nashi homolog, MAGOH, MAGOHA
Target/Specificity This MAGOH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the Central region of human MAGOH.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGOH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAGOHA
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.
Cellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Tissue Location Ubiquitous.
Citations (0)

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Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.


Gehring, N.H., et al. Cell 137(3):536-548(2009)
Muromoto, R., et al. Biochem. Biophys. Res. Commun. 382(1):63-68(2009)
Diem, M.D., et al. Nat. Struct. Mol. Biol. 14(12):1173-1179(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Andersen, C.B., et al. Science 313(5795):1968-1972(2006)

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$ 295.00
$ 99.00
Cat# AP14367c
(40 western blots)
Availability: In Stock
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