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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FRAT1 Antibody (Center)   

FRAT1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FRAT1 Antibody (Center) AP1436c
    Western blot analysis of FRAT1 (arrow) using rabbit polyclonal FRAT1 Antibody (Center) (Cat.#AP1436c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FRAT1 gene (Lane 2) (Origene Technologies).
  • IHC-P - FRAT1 Antibody (Center) AP1436c
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with FRAT1 antibody (Center) (Cat.#AP1436c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92837
Other Accession O75474
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29093 Da
Antigen Region 99-128 aa
Additional Information
Gene ID 10023
Other Names Proto-oncogene FRAT1, Frequently rearranged in advanced T-cell lymphomas 1, FRAT-1, FRAT1
Target/Specificity This FRAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-128 amino acids from the Central region of human FRAT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFRAT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FRAT1
Function Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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FRAT1 belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis. It positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. It may play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.


Hagen,T., J. Biol. Chem. 281 (46), 35021-35029 (2006)
Wang,Y., Br. J. Cancer 94 (5), 686-691 (2006)
Hino,S., J. Biol. Chem. 278 (16), 14066-14073 (2003)

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Cat# AP1436c
(40 western blots)
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