|Application ||WB, IHC-P, E|
|Calculated MW||29093 Da|
|Antigen Region||99-128 aa|
|Other Names||Proto-oncogene FRAT1, Frequently rearranged in advanced T-cell lymphomas 1, FRAT-1, FRAT1|
|Target/Specificity||This FRAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-128 amino acids from the Central region of human FRAT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRAT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.|
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Provided below are standard protocols that you may find useful for product applications.
FRAT1 belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis. It positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. It may play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Hagen,T., J. Biol. Chem. 281 (46), 35021-35029 (2006)
Wang,Y., Br. J. Cancer 94 (5), 686-691 (2006)
Hino,S., J. Biol. Chem. 278 (16), 14066-14073 (2003)
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