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CARD10 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CARD10 Antibody (Center) AP14373C
    CARD10 Antibody (Center) (Cat. #AP14373c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CARD10 antibody detected the CARD10 protein (arrow).
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BWT7
Other Accession NP_055365.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 115931 Da
Antigen Region 518-546 aa
Additional Information
Gene ID 29775
Other Names Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3, CARD10, CARMA3
Target/Specificity This CARD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-546 amino acids from the Central region of human CARD10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCARD10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD10
Synonyms CARMA3
Function Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.
Cellular Location Cytoplasm.
Tissue Location Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney
Research Areas
Citations (0)
citation

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Background

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)
Martin, D., et al. J. Biol. Chem. 284(10):6038-6042(2009)

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$ 182.50
$ 70.00
Cat# AP14373C
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