|Application ||WB, E|
|Calculated MW||115931 Da|
|Antigen Region||518-546 aa|
|Other Names||Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3, CARD10, CARMA3|
|Target/Specificity||This CARD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-546 amino acids from the Central region of human CARD10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CARD10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates NF-kappa-B via BCL10 and IKK.|
|Tissue Location||Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)
Martin, D., et al. J. Biol. Chem. 284(10):6038-6042(2009)
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