|Application ||WB, E|
|Other Accession||O08842, NP_001486.4, NP_001158510.1, NP_001158511.1|
|Calculated MW||51544 Da|
|Antigen Region||361-390 aa|
|Other Names||GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, GDNFR-beta, Neurturin receptor alpha, NRTNR-alpha, NTNR-alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GFRA2, GDNFRB, RETL2, TRNR2|
|Target/Specificity||This GFRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human GFRA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GFRA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GDNFRB, RETL2, TRNR2|
|Function||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Isoform 1 is found in both brain and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Souza, R.P., et al. J Psychiatr Res 44(11):700-706(2010)
Souza, R.P., et al. Psychopharmacology (Berl.) 210(3):347-354(2010)
Buysschaert, I.D., et al. Allergy 65(5):616-622(2010)
Lavedan, C., et al. Mol. Psychiatry 14(8):804-819(2009)
Volpi, S., et al. J Clin Psychiatry 70(6):801-809(2009)
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