|Application ||WB, E|
|Other Accession||NP_062817.2, NP_001157974.1|
|Calculated MW||108201 Da|
|Antigen Region||80-108 aa|
|Other Names||Eukaryotic translation initiation factor 4E transporter, 4E-T, eIF4E transporter, Eukaryotic translation initiation factor 4E nuclear import factor 1, EIF4ENIF1|
|Target/Specificity||This EIF4ENIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the N-terminal region of human EIF4ENIF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EIF4ENIF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.
Suzuki, Y., et al. J. Biol. Chem. 284(51):35597-35604(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Lee, H.C., et al. Biochem. Biophys. Res. Commun. 369(4):1160-1165(2008)
Denoeud, F., et al. Genome Res. 17(6):746-759(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
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