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STEAP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9UHE8 |
| Other Accession | NP_036581.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39851 Da |
| Antigen Region | 2-31 aa |
| Gene ID | 26872 |
|---|---|
| Other Names | Metalloreductase STEAP1, 1161-, Six-transmembrane epithelial antigen of prostate 1, STEAP1, PRSS24, STEAP |
| Target/Specificity | This STEAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human STEAP1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STEAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STEAP1 |
|---|---|
| Synonyms | PRSS24, STEAP |
| Function | Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q9CWR7}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. Highly expressed in prostate tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
References
Valenti, M.T., et al. J. Endocrinol. Invest. 33(4):244-249(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Vaghjiani, R.J., et al. Tissue Eng Part A 15(8):2073-2083(2009)
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Maia, C.J., et al. Endocrine 34 (1-3), 108-116 (2008) :
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