|Application ||WB, IHC-P, E|
|Calculated MW||30846 Da|
|Antigen Region||206-234 aa|
|Other Names||Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase, QPRTase, QPRT|
|Target/Specificity||This QPRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the C-terminal region of human QPRT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||QPRT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the catabolism of quinolinic acid (QA).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
Hinsch, N., et al. BMC Cancer 9, 93 (2009) :
Liu, H., et al. J. Mol. Biol. 373(3):755-763(2007)
Magni, G., et al. Cell. Mol. Life Sci. 61(1):19-34(2004)
Fukuoka, S., et al. Adv. Exp. Med. Biol. 467, 611-614 (1999) :
Fukuoka, S.I., et al. Biochim. Biophys. Acta 1395(2):192-201(1998)
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