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CTDSP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14595 |
| Other Accession | NP_005721.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30664 Da |
| Antigen Region | 11-39 aa |
| Gene ID | 10106 |
|---|---|
| Other Names | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2, CTDSP2, NIF2, OS4, SCP2 |
| Target/Specificity | This CTDSP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human CTDSP2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTDSP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTDSP2 |
|---|---|
| Synonyms | NIF2, OS4, SCP2 |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |
| Cellular Location | Nucleus. |
| Tissue Location | Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Sapkota, G., et al. J. Biol. Chem. 281(52):40412-40419(2006)
Thompson, J., et al. EMBO J. 25(12):2757-2767(2006)
Yeo, M., et al. J. Biol. Chem. 278(28):26078-26085(2003)
Su, Y.A., et al. Oncogene 15(11):1289-1294(1997)
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