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POTE Antibody (C-term L446)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q86YR6 |
| Other Accession | B2RU33 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66394 Da |
| Antigen Region | 438-468 aa |
| Gene ID | 100288966;317754 |
|---|---|
| Other Names | POTE ankyrin domain family member D, ANKRD26-like family B member 3, Ankyrin repeat domain-containing protein 21, Prostate, ovary, testis-expressed protein, Protein POTE, POTED, A26B3, ANKRD21, POTE |
| Target/Specificity | This POTE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438~468 amino acids from the C-term region of human POTE. |
| Dilution | WB~~1:500 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | POTE Antibody (C-term L446) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POTED |
|---|---|
| Synonyms | A26B3, ANKRD21, POTE |
| Cellular Location | Cell membrane; Peripheral membrane protein |
| Tissue Location | Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
POTE, is a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. The POTE protein contains seven ankyrin repeats between amino acids 140 and 380. Expression of POTE in prostate cancer and its undetectable expression in normal essential tissues make POTE a candidate for the immunotherapy of prostate cancer. The existence of a large number of closely related but rapidly diverging members, their location on multiple chromosomes and their limited expression pattern suggest an important role for the POTE gene family in reproductive processes.
References
Bera T.K., Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002).
Bera,T.K., Gene 337, 45-53 (2004)
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