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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NANOS1 Antibody (Center)   

NANOS1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NANOS1 Antibody (Center) AP14401c
    NANOS1 Antibody (Center) (Cat. #AP14401c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NANOS1 antibody detected the NANOS1 protein (arrow).
  • IHC-P - NANOS1 Antibody (Center) AP14401c
    NANOS1 Antibody (Center) (AP14401c)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NANOS1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WY41
Other Accession NP_955631.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30230 Da
Antigen Region 96-124 aa
Additional Information
Gene ID 340719
Other Names Nanos homolog 1, NOS-1, EC_Rep1a, NANOS1, NOS1
Target/Specificity This NANOS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human NANOS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNANOS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NOS1
Function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Cellular Location Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells
Tissue Location Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness
Research Areas
Citations (0)

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NANOS1 may regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets.


Ginter-Matuszewska, B., et al. Mol. Hum. Reprod. 15(3):173-179(2009)
Bonnomet, A., et al. Oncogene 27(26):3692-3699(2008)
Strumane, K., et al. Cancer Res. 66(20):10007-10015(2006)
Kurokawa, H., et al. Dev. Growth Differ. 48(3):209-221(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)

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$ 295.00
$ 99.00
Cat# AP14401c
(40 western blots)
Availability: In Stock
Bulk Size
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