|Application ||WB, E|
|Calculated MW||36567 Da|
|Antigen Region||1-30 aa|
|Other Names||Zinc finger protein ZIC 4, Zinc finger protein of the cerebellum 4, ZIC4|
|Target/Specificity||This ZIC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ZIC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZIC4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to DNA.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene.
Grinberg, I., et al. Clin. Genet. 67(4):290-296(2005)
Jaster, J.H. Neurology 63 (7), 1339 (2004) :
Grinberg, I., et al. Nat. Genet. 36(10):1053-1055(2004)
Ohtsuka, M., et al. Genomics 83(6):1063-1071(2004)
Bataller, L., et al. Neurology 62(5):778-782(2004)
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