|Application ||WB, IHC-P, E|
|Calculated MW||40956 Da|
|Antigen Region||210-238 aa|
|Other Names||Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor, PTGIR, PRIPR|
|Target/Specificity||This PTGIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of human PTGIR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTGIR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ibrahim, S., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1802-1809(2010)
Reid, H.M., et al. J. Biol. Chem. 285(24):18709-18726(2010)
Muto, A., et al. Int Angiol 29 (2 SUPPL), 43-48 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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