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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRIK2 Antibody (C-term)   

GRIK2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GRIK2 Antibody (C-term) AP14429B
    GRIK2 Antibody (C-term) (Cat. #AP14429b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GRIK2 antibody detected the GRIK2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13002
Other Accession Q91755, P42260, P39087, Q38PU3, NP_786944.1, NP_068775.1, NP_001159719.1
Reactivity Human
Predicted Monkey, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102583 Da
Antigen Region 828-856 aa
Additional Information
Gene ID 2898
Other Names Glutamate receptor ionotropic, kainate 2, GluK2, Excitatory amino acid receptor 4, EAA4, Glutamate receptor 6, GluR-6, GluR6, GRIK2, GLUR6
Target/Specificity This GRIK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-856 amino acids from the C-terminal region of human GRIK2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRIK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIK2
Synonyms GLUR6
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
Tissue Location Expression is higher in cerebellum than in cerebral cortex
Research Areas
Citations (0)

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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.


Han, Y., et al. Biochemistry 49(43):9207-9216(2010)
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sampaio, A.S., et al. CNS Neurosci Ther (2010) In press :
Sander, T., et al. Neurology 45(9):1713-1720(1995)

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$ 295.00
$ 99.00
Cat# AP14429B
(40 western blots)
Availability: In Stock
Bulk Size
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