|Application ||WB, E|
|Other Accession||Q91755, P42260, P39087, Q38PU3, NP_786944.1, NP_068775.1, NP_001159719.1|
|Predicted||Monkey, Mouse, Rat, Xenopus|
|Calculated MW||102583 Da|
|Antigen Region||828-856 aa|
|Other Names||Glutamate receptor ionotropic, kainate 2, GluK2, Excitatory amino acid receptor 4, EAA4, Glutamate receptor 6, GluR-6, GluR6, GRIK2, GLUR6|
|Target/Specificity||This GRIK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 828-856 amino acids from the C-terminal region of human GRIK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRIK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
|Tissue Location||Expression is higher in cerebellum than in cerebral cortex|
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Provided below are standard protocols that you may find useful for product applications.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
Han, Y., et al. Biochemistry 49(43):9207-9216(2010)
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sampaio, A.S., et al. CNS Neurosci Ther (2010) In press :
Sander, T., et al. Neurology 45(9):1713-1720(1995)
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