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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PCDHB1 Antibody (C-term)   

PCDHB1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PCDHB1 Antibody (C-term) AP14438B
    PCDHB1 Antibody (C-term) (Cat. #AP14438b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCDHB1 antibody detected the PCDHB1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y5F3
Other Accession NP_037472.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 782-811 aa
Additional Information
Other Names Protocadherin beta-1, PCDH-beta-1, PCDHB1
Target/Specificity This PCDHB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782-811 amino acids from the C-terminal region of human PCDHB1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPCDHB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHB1
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein EMBL; AF152488; AAD43749.1; -; mRNA EMBL; CH471062; EAW61985.1; -; Genomic_DNA EMBL; BC112096; AAI12097.1; -; mRNA EMBL; BC112098; AAI12099.1; -; mRNA CCDS; CCDS4243.1; - RefSeq; NP_037472.2; NM_013340.3 UniGene; Hs.278950; - ProteinModelPortal; Q9Y5F3; - SMR; Q9Y5F3; - BioGrid; 118971; 21 iPTMnet; Q9Y5F3; - PhosphoSitePlus; Q9Y5F3; - BioMuta; PCDHB1; - DMDM; 205371811; - PaxDb; Q9Y5F3; - PeptideAtlas; Q9Y5F3; - PRIDE; Q9Y5F3; - ProteomicsDB; 86352; - Ensembl; ENST00000306549; ENSP00000307234; ENSG00000171815 GeneID; 29930; - KEGG; hsa:29930; - UCSC; uc003lik.3; human CTD; 29930; - EuPathDB; HostDB:ENSG00000171815.5; - GeneCards; PCDHB1; - HGNC; HGNC:8680; PCDHB1 HPA; HPA053921; - MIM; 604967; gene MIM; 606327; gene neXtProt; NX_Q9Y5F3; - OpenTargets; ENSG00000171815; - PharmGKB; PA33025; - eggNOG; KOG3594; Eukaryota eggNOG; ENOG410XQHI; LUCA GeneTree; ENSGT00920000148964; - HOGENOM; HOG000220892; - HOVERGEN; HBG054878; - InParanoid; Q9Y5F3; - KO; K16494; - OMA; MILYPLQ; - OrthoDB; EOG091G024L; - PhylomeDB; Q9Y5F3; - TreeFam; TF332299; - GenomeRNAi; 29930; - PRO; PR:Q9Y5F3; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000171815; - CleanEx; HS_PCDHB1; - Genevisible; Q9Y5F3; HS GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0007155; P:cell adhesion; IBA:GO_Central GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro GO; GO:0007416; P:synapse assembly; IBA:GO_Central InterPro; IPR002126; Cadherin InterPro; IPR015919; Cadherin-like InterPro; IPR032455; Cadherin_C InterPro; IPR020894; Cadherin_CS InterPro; IPR013164; Cadherin_N InterPro; IPR030723; PCDHB1 PANTHER; PTHR24028:SF12; PTHR24028:SF12; 1 Pfam; PF00028; Cadherin; 5 Pfam; PF08266; Cadherin_2; 1 Pfam; PF16492; Cadherin_C_2; 1 PRINTS; PR00205; CADHERIN SMART; SM00112; CA; 6 SUPFAM; SSF49313; SSF49313; 6 PROSITE; PS00232; CADHERIN_1; 5 PROSITE; PS50268; CADHERIN_2; 6 2: Evidence at transcript level; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 28 CHAIN 29 818 Protocadherin beta-1 /FTId=PRO_0000003914 TOPO_DOM 29 691 Extracellular. TRANSMEM 692 712 Helical. TOPO_DOM 713 818 Cytoplasmic. DOMAIN 35 133 Cadherin 1. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 138 242 Cadherin 2. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 243 347 Cadherin 3. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 348 452 Cadherin 4. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 457 562 Cadherin 5. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 577 672 Cadherin 6. {ECO:0000255|PROSITE- ProRule:PRU00043} CARBOHYD 169 169 N-linked (GlcNAc...) asparagine CARBOHYD 209 209 N-linked (GlcNAc...) asparagine CARBOHYD 257 257 N-linked (GlcNAc...) asparagine CARBOHYD 419 419 N-linked (GlcNAc...) asparagine CARBOHYD 568 568 N-linked (GlcNAc...) asparagine VARIANT 385 385 F -> L (in dbSNP:rs2233591) /FTId=VAR_048541 VARIANT 390 390 L -> F (in dbSNP:rs2233592) /FTId=VAR_048542 VARIANT 524 524 A -> V (in dbSNP:rs17208383) /FTId=VAR_048543 VARIANT 611 611 T -> I (in dbSNP:rs10476822) /FTId=VAR_048544 VARIANT 712 712 I -> T (in dbSNP:rs31738) /FTId=VAR_048545 VARIANT 719 719 K -> I (in dbSNP:rs2233595) /FTId=VAR_048546 VARIANT 778 778 F -> L (in dbSNP:rs246679) /FTId=VAR_048547 SEQUENCE 818 AA; 90491 MW; 4697DC76EDB7D604 CRC64; MAGTRRKSLQ NRQVGSLLIF LCISVGDATT IRYSVAEEME SGSFVANVAK DLGLEVGKLA ARGARLVSEG NKMHFRLHRK TGDLFVKEKL DRESLCGKAD PCVLHFEVVL VEPLQSFRAE VRVFDINDNA PVFLNKEPLL KIPESTPLGS RFPLQSAQDL DVGLNGLQNY TLSANGYFHL HTRFCSHGPK YAELVLNKPL DREEQPEVNL TITAVDGGSP PKSGTAHIHV VVLDVNDHVP QFSRLVYRAQ VSENSPNGSL VATVTAVDLD EGTNKAITYS LAQNPEAILK TFQIDPQNGE VRLRGPLDFE AIETYDIDIQ ATDGGGLSAH SKVLVEVVDV NDNPPEVMVS SVSSPLPEDS PPQTVVALFT IRDRDIRVGG KVTCFLREDL PFVIKPTFGN SYSLVTDRSL DREEVSGYNI TIVAMDTGPP SLSAETMIEV LISDVNDNPP IFREDSYILT VRENNSPAVF IGKVHAEDLD LGENAQITYS LLPPKNGDLS VFAYISINSG NGKLYALRTM DYEAIQDFQF VVKATDGGFL SLSSQVTVRV VVLDDNDNRP MILYPLQNGT LPCNDLVPRS AEAGYLVTKV VAVDGDSGQN SWLSYHLLKA TDLGLFSVQR QNGEIHTLRQ ISERDPMMQK LIILVQDHGQ PALSTTVSLN ILLVDGFSEP YLQFQDPTKH SRKVNPSTKY LVISLVILSF LFLLSVIVIF IIHVYQKIKY REKFTIQEHF YDDCNFSNNL VQGQGNGSLS RPCPYEMCSA TGTGNSEFRF LKRFMPNFPF PHATGEIKME AGSSLPPNSD RNKSQRLEGH DQVSDDYM
Research Areas
Citations (0)

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Background

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

References

Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :
Wu, Q., et al. Genome Res. 11(3):389-404(2001)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)

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$ 295.00
$ 99.00
Cat# AP14438B
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(40 western blots)
Availability: In Stock
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