|Application ||WB, E|
|Calculated MW||16453 Da|
|Antigen Region||95-124 aa|
|Other Names||Galectin-10, Gal-10, Charcot-Leyden crystal protein, CLC, Eosinophil lysophospholipase, Lysolecithin acylhydrolase, CLC, LGALS10, LGALS10A|
|Target/Specificity||This CLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the C-terminal region of human CLC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).|
|Cellular Location||Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell|
|Tissue Location||Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Bryborn, M., et al. Allergy 65(2):220-228(2010)
De Re, V., et al. Ann. N. Y. Acad. Sci. 1173, 357-364 (2009) :
Than, N.G., et al. Proc. Natl. Acad. Sci. U.S.A. 106(24):9731-9736(2009)
Kubach, J., et al. Blood 110(5):1550-1558(2007)
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