|Application ||WB, IHC-P, E|
|Calculated MW||33249 Da|
|Antigen Region||16-46 aa|
|Other Names||Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2|
|Target/Specificity||This Stanniocalcin-2 (STC2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human Stanniocalcin-2 (STC2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Stanniocalcin-2 (STC2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has an anti-hypocalcemic action on calcium and phosphate homeostasis.|
|Tissue Location||Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
STC2 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression is induced by estrogen and altered in some breast cancers.
Ishibashi, K., et al., Biochem. Biophys. Res. Commun. 250(2):252-258 (1998).
DiMattia, G.E., et al., Mol. Cell. Endocrinol. 146 (1-2), 137-140 (1998).
Chang, A.C., et al., Mol. Cell. Endocrinol. 141 (1-2), 95-99 (1998).
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