|Application ||WB, IHC-P, E|
|Other Accession||Q63454, NP_766220.2|
|Calculated MW||65574 Da|
|Antigen Region||67-94 aa|
|Other Names||Mitogen-activated protein kinase 4, MAP kinase 4, MAPK 4, Extracellular signal-regulated kinase 4, ERK-4, Mapk4, Erk4, Prkm4|
|Target/Specificity||This Mouse Mapk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the N-terminal region of mouse Mapk4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mapk4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
Klinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16710-16715(2009)
Kesavan, C., et al. Bone 41(2):223-230(2007)
Kant, S., et al. J. Biol. Chem. 281(46):35511-35519(2006)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Xu, H., et al. J. Biol. Chem. 278(32):30187-30192(2003)
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