|Application ||WB, IHC-P, E|
|Other Accession||Q63454, NP_766220.2|
|Calculated MW||65574 Da|
|Antigen Region||67-94 aa|
|Other Names||Mitogen-activated protein kinase 4, MAP kinase 4, MAPK 4, Extracellular signal-regulated kinase 4, ERK-4, Mapk4, Erk4, Prkm4|
|Target/Specificity||This Mouse Mapk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the N-terminal region of mouse Mapk4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mapk4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
Klinger, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16710-16715(2009)
Kesavan, C., et al. Bone 41(2):223-230(2007)
Kant, S., et al. J. Biol. Chem. 281(46):35511-35519(2006)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Xu, H., et al. J. Biol. Chem. 278(32):30187-30192(2003)
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