Mouse Nek9 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8K1R7 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 107143 Da |
Antigen Region | 503-530 aa |
Gene ID | 217718 |
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Other Names | Serine/threonine-protein kinase Nek9, Nercc1 kinase, Never in mitosis A-related kinase 9, NimA-related protein kinase 9, Nek9, Nercc |
Target/Specificity | This Mouse Nek9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 503-530 amino acids from the Central region of mouse Nek9. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Nek9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Nek9 {ECO:0000303|PubMed:26522158, ECO:0000312|MGI:MGI:2387995} |
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Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8TD19}. Nucleus {ECO:0000250|UniProtKB:Q8TD19} |
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Background
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression (By similarity).
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