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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Prkaca/Prkacb Antibody (C-term)   

Mouse Prkaca/Prkacb Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Prkaca/Prkacb Antibody (C-term) AP14456B
    Mouse Prkaca/Prkacb Antibody (C-term) (Cat. #AP14456b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the Prkaca/Prkacb antibody detected the Prkaca/Prkacb protein (arrow).
  • WB - Mouse Prkaca/Prkacb Antibody (C-term) AP14456B
    Mouse Prkaca/Prkacb Antibody (C-term) (Cat. #AP14456b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Prkaca/Prkacb antibody detected the Prkaca/Prkacb protein (arrow).
  • IHC-P - Mouse Prkaca/Prkacb Antibody (C-term) AP14456B
    Mouse Prkaca/Prkacb Antibody (C-term) (AP14456b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Prkaca/Prkacb Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P68181
Other Accession P68182, P05383, P22694, P68180, P05131, P27791, P36887, P05132, P17612, P25321, P00517, NP_001157672.1, NP_001157670.1, Q9MZD9
Reactivity Human, Mouse
Predicted Bovine, Hamster, Pig, Rat, Sheep
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40708 Da
Antigen Region 292-319 aa
Additional Information
Gene ID 18749
Other Names cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, Prkacb, Pkacb
Target/Specificity This Mouse Prkaca/Prkacb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-319 amino acids from the C-terminal region of mouse Prkaca/Prkacb.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Prkaca/Prkacb Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Prkacb
Synonyms Pkacb
Function Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).
Cellular Location Cytoplasm. Cell membrane. Membrane {ECO:0000250|UniProtKB:P22694}; Lipid- anchor {ECO:0000250|UniProtKB:P22694}. Nucleus Note=Translocates into the nucleus (monomeric catalytic subunit) The inactive holoenzyme is found in the cytoplasm.
Tissue Location Isoform 1 is found in all tissues examined, with the highest expression in the brain and very low levels in the testis. Isoform 2 is strongly expressed in the brain, in the prelimbic and insular cortex. Isoform 3 is also found only in the brain, but at very low levels.
Research Areas
Citations (0)

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Background

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.

References

Ribeiro, R.A., et al. Br. J. Nutr. 104(8):1148-1155(2010)
Liu, J.X., et al. Seizure 19(7):414-420(2010)
Ha, C.H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15467-15472(2010)
Sarma, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(29):13165-13170(2010)
Rah, S.Y., et al. J. Biol. Chem. 285(28):21877-21887(2010)

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$ 295.00
$ 99.00
Cat# AP14456B
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(40 western blots)
Availability: In Stock
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