|Application ||WB, IHC-P, E|
|Other Accession||P68182, P05383, P22694, P68180, P05131, P27791, P36887, P05132, P17612, P25321, P00517, NP_001157672.1, NP_001157670.1, Q9MZD9|
|Predicted||Bovine, Hamster, Pig, Rat|
|Calculated MW||40708 Da|
|Antigen Region||292-319 aa|
|Other Names||cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, Prkacb, Pkacb|
|Target/Specificity||This Mouse Prkaca/Prkacb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-319 amino acids from the C-terminal region of mouse Prkaca/Prkacb.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Prkaca/Prkacb Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.|
|Tissue Location||Isoform 1 is found in all tissues examined, with the highest expression in the brain and very low levels in the testis. Isoform 2 is strongly expressed in the brain, in the prelimbic and insular cortex. Isoform 3 is also found only in the brain, but at very low levels.|
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Provided below are standard protocols that you may find useful for product applications.
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
Ribeiro, R.A., et al. Br. J. Nutr. 104(8):1148-1155(2010)
Liu, J.X., et al. Seizure 19(7):414-420(2010)
Ha, C.H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15467-15472(2010)
Sarma, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(29):13165-13170(2010)
Rah, S.Y., et al. J. Biol. Chem. 285(28):21877-21887(2010)
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