|Application ||WB, E|
|Calculated MW||140602 Da|
|Antigen Region||506-534 aa|
|Other Names||Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, Map4k4, Nik|
|Target/Specificity||This Mouse Map4k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from the Central region of mouse Map4k4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Map4k4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity).|
|Tissue Location||Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
Maruyama, T., et al. J. Bone Miner. Res. 25(5):1058-1067(2010)
Guntur, K.V., et al. J. Biol. Chem. 285(9):6595-6603(2010)
Aouadi, M., et al. Nature 458(7242):1180-1184(2009)
Wittwer, T., et al. Biochem. Biophys. Res. Commun. 371(2):294-297(2008)
Tesz, G.J., et al. J. Biol. Chem. 282(27):19302-19312(2007)
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