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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Map4k4 Antibody (Center)   

Mouse Map4k4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Map4k4 Antibody (Center) AP14459C
    Mouse Map4k4 Antibody (Center) (Cat. #AP14459c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the Map4k4 antibody detected the Map4k4 protein (arrow).
  • WB - Mouse Map4k4 Antibody (Center) AP14459C
    Mouse Map4k4 Antibody (Center) (Cat. #AP14459c) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Map4k4 antibody detected the Map4k4 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P97820
Other Accession NP_032722.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 140602 Da
Antigen Region 506-534 aa
Additional Information
Gene ID 26921
Other Names Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, Map4k4, Nik
Target/Specificity This Mouse Map4k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from the Central region of mouse Map4k4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Map4k4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Map4k4
Synonyms Nik
Function Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity).
Cellular Location Cytoplasm.
Tissue Location Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain
Research Areas
Citations (0)

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Background

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.

References

Maruyama, T., et al. J. Bone Miner. Res. 25(5):1058-1067(2010)
Guntur, K.V., et al. J. Biol. Chem. 285(9):6595-6603(2010)
Aouadi, M., et al. Nature 458(7242):1180-1184(2009)
Wittwer, T., et al. Biochem. Biophys. Res. Commun. 371(2):294-297(2008)
Tesz, G.J., et al. J. Biol. Chem. 282(27):19302-19312(2007)

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$ 295.00
$ 99.00
Cat# AP14459C
Size:
Quantity:
(40 western blots)
Availability: In Stock
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