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Mouse Map4k4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P97820 |
| Other Accession | NP_032722.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 140602 Da |
| Antigen Region | 506-534 aa |
| Gene ID | 26921 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, Map4k4, Nik |
| Target/Specificity | This Mouse Map4k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from the Central region of mouse Map4k4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Map4k4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Map4k4 |
|---|---|
| Synonyms | Nik |
| Function | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
References
Maruyama, T., et al. J. Bone Miner. Res. 25(5):1058-1067(2010)
Guntur, K.V., et al. J. Biol. Chem. 285(9):6595-6603(2010)
Aouadi, M., et al. Nature 458(7242):1180-1184(2009)
Wittwer, T., et al. Biochem. Biophys. Res. Commun. 371(2):294-297(2008)
Tesz, G.J., et al. J. Biol. Chem. 282(27):19302-19312(2007)
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