|Application ||WB, E|
|Calculated MW||27213 Da|
|Antigen Region||19-48 aa|
|Other Names||Ubiquitin thioesterase OTUB2, Deubiquitinating enzyme OTUB2, OTU domain-containing ubiquitin aldehyde-binding protein 2, Otubain-2, Ubiquitin-specific-processing protease OTUB2, OTUB2, C14orf137, OTB2, OTU2|
|Target/Specificity||This OTUB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human OTUB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OTUB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C14orf137, OTB2, OTU2|
|Function||Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'- linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.|
|Tissue Location||Widely expressed. Expressed at higher level in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Otubains are deubiquitylating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.
Li, S., et al. J. Biol. Chem. 285(7):4291-4297(2010)
Sowa, M.E., et al. Cell 138(2):389-403(2009)
Edelmann, M.J., et al. Biochem. J. 418(2):379-390(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Nanao, M.H., et al. EMBO Rep. 5(8):783-788(2004)
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