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MFSD2B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | A6NFX1 |
| Other Accession | B5MC32, NP_001073942.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53743 Da |
| Antigen Region | 383-411 aa |
| Gene ID | 388931 |
|---|---|
| Other Names | Major facilitator superfamily domain-containing protein 2B, MFSD2B |
| Target/Specificity | This MFSD2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-411 amino acids from the C-terminal region of human MFSD2B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MFSD2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MFSD2B {ECO:0000303|PubMed:29045386, ECO:0000312|HGNC:HGNC:37207} |
|---|---|
| Function | Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Localizes to the cell membrane and intracellular membranes. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Angers, M., et al. Biochem. J. 416(3):347-355(2008)
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$ 365.00
$ 140.00
Cat# AP14483b
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