|Application ||WB, IHC-P, E|
|Calculated MW||21932 Da|
|Antigen Region||1-30 aa|
|Other Names||Myosin light chain 3, Cardiac myosin light chain 1, CMLC1, Myosin light chain 1, slow-twitch muscle B/ventricular isoform, MLC1SB, Ventricular/slow twitch myosin alkali light chain, MYL3|
|Target/Specificity||This MYL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MYL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory light chain of myosin. Does not bind calcium.|
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Provided below are standard protocols that you may find useful for product applications.
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Girolami, F., et al. J. Am. Coll. Cardiol. 55(14):1444-1453(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
McLeod, C.J., et al. Am. Heart J. 158(5):799-805(2009)
Kaski, J.P., et al. Circ Cardiovasc Genet 2(5):436-441(2009)
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