|Application ||WB, E|
|Other Accession||Q0VC65, NP_001978.1|
|Calculated MW||53000 Da|
|Antigen Region||173-202 aa|
|Other Names||Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1|
|Target/Specificity||This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human ETV6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ETV6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
Otsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)
Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)
Liang, D.C., et al. Pediatr Blood Cancer 55(3):430-433(2010)
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