|Application ||WB, E|
|Other Accession||NP_003865.1, NP_001171808.1|
|Calculated MW||38782 Da|
|Antigen Region||232-260 aa|
|Other Names||SLAM family member 5, Cell surface antigen MAX3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, CD84, SLAMF5|
|Target/Specificity||This CD84 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-260 amino acids from the C-terminal region of human CD84.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD84 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.
Oliver-Vila, I., et al. Mol. Immunol. 45(8):2138-2149(2008)
Yan, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 104(25):10583-10588(2007)
Nanda, N., et al. Blood 106(9):3028-3034(2005)
Romero, X., et al. Tissue Antigens 64(2):132-144(2004)
Zaiss, M., et al. Exp. Hematol. 31(9):798-805(2003)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.