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KLF1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KLF1 Antibody (C-term) AP14499b
    KLF1 Antibody (C-term) (Cat. #AP14499b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the KLF1 antibody detected the KLF1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13351
Other Accession NP_006554.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38221 Da
Antigen Region 248-276 aa
Additional Information
Gene ID 10661
Other Names Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
Target/Specificity This KLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the C-terminal region of human KLF1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLF1
Synonyms EKLF
Function Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Cellular Location Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles.
Tissue Location Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines
Research Areas
Citations (0)

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This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.


Borg, J., et al. Nat. Genet. 42(9):801-805(2010)
Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Papachatzopoulou, A., et al. Hemoglobin 34(4):333-342(2010)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)

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$ 295.00
$ 99.00
Cat# AP14499b
(40 western blots)
Availability: In Stock
Bulk Size
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