|Application ||WB, IHC-P, E|
|Other Accession||P34064, Q9Z2U1, Q95083, Q95008, Q5E987|
|Predicted||Bovine, C.Elegans, Drosophila, Mouse, Rat|
|Calculated MW||26411 Da|
|Antigen Region||1-30 aa|
|Other Names||Proteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5|
|Target/Specificity||This PSMA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PSMA5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSMA5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed in fetal brain (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PMA5 is a member of the peptidase T1A family, that is a 20S core alpha subunit.
Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)
Gregory,S.G., Nature 441 (7091), 315-321 (2006)
Beausoleil,S.A., Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
Conticello,S.G., Curr. Biol. 13 (22), 2009-2013 (2003)
Yu,X., Science 302 (5647), 1056-1060 (2003)
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