|Application ||WB, IHC-P, E|
|Calculated MW||50477 Da|
|Antigen Region||44-73 aa|
|Other Names||Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1, SPRED1|
|Target/Specificity||This SPRED1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the N-terminal region of human SPRED1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRED1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions|
|Tissue Location||Weakly expressed in embryonic cell line HEK293.|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
SPRED1 is a tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
Brems,H., Nat. Genet. 39 (9), 1120-1126 (2007)
Szafranski,K., Genome Biol. 8 (8), R154 (2007)
Yoshida,T., Oncogene 25 (45), 6056-6066 (2006)
King,J.A., Biochem. J. 388 (PT 2), 445-454 (2005)
If you have any additional inquiries please email technical services at email@example.com.