|Application ||WB, IHC-P, E|
|Other Accession||NP_001012650.1, NP_001012649.1|
|Calculated MW||26676 Da|
|Antigen Region||24-53 aa|
|Other Names||Interleukin-32, IL-32, Natural killer cells protein 4, Tumor necrosis factor alpha-inducing factor, IL32, NK4, TAIF|
|Target/Specificity||This IL32 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human IL32.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL32 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF- alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.|
|Tissue Location||Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Li, W., et al. J. Immunol. 185(9):5056-5065(2010)
Cho, K.A., et al. Microb. Pathog. 49(3):95-104(2010)
Kobori, A., et al. World J. Gastroenterol. 16(19):2355-2361(2010)
Yue, D., et al. Asian J. Androl. 12(3):381-389(2010)
Chae, J.I., et al. Cell. Immunol. 264(1):47-53(2010)
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