|Application ||WB, E|
|Other Accession||P70426, NP_008843.1|
|Calculated MW||25145 Da|
|Antigen Region||41-70 aa|
|Other Names||GTP-binding protein Rit1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, RIT1, RIBB, RIT, ROC1|
|Target/Specificity||This RIT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human RIT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RIT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RIBB, RIT, ROC1|
|Function||Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.|
|Cellular Location||Cell membrane.|
|Tissue Location||Expressed in many tissues.|
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Provided below are standard protocols that you may find useful for product applications.
RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003 [PubMed 12668729]).[supplied by OMIM].
Lee, Y.R., et al. EMBO J. 29(10):1748-1761(2010)
Katiyar, S., et al. EMBO Rep. 10(8):866-872(2009)
Sonuga-Barke, E.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1359-1368 (2008) :
Hu, J., et al. Genes Dev. 22(7):866-871(2008)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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