|Application ||WB, E|
|Other Accession||Q1AAU6, Q9QWY8, O97902, NP_060952.2|
|Calculated MW||125498 Da|
|Antigen Region||360-388 aa|
|Other Names||Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1, 130 kDa phosphatidylinositol 4, 5-bisphosphate-dependent ARF1 GTPase-activating protein, ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, DEF-1, Differentiation-enhancing factor 1, PIP2-dependent ARF1 GAP, ASAP1, DDEF1, KIAA1249|
|Target/Specificity||This ASAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human ASAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASAP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.|
|Cellular Location||Cytoplasm. Membrane. Note=Predominantly cytoplasmic. Partially membrane- associated.|
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Possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity).
Muller, T., et al. Oncogene 29(16):2393-2403(2010)
Nat. Genet. 41(7):824-828(2009)
Jian, X., et al. J. Biol. Chem. 284(3):1652-1663(2009)
Inoue, H., et al. Mol. Biol. Cell 19(10):4224-4237(2008)
Lin, D., et al. Cancer Res. 68(11):4352-4359(2008)
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