|Application ||WB, IHC-P, E|
|Calculated MW||21386 Da|
|Antigen Region||162-191 aa|
|Other Names||p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, KCP-1, P53-induced protein PIGPC1, Transmembrane protein THW, PERP, KCP1, KRTCAP1, PIGPC1, THW|
|Target/Specificity||This PERP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the C-terminal region of human PERP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PERP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KCP1, KRTCAP1, PIGPC1, THW|
|Function||Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).|
|Cellular Location||Cell junction, desmosome. Cell membrane; Multi-pass membrane protein Note=Associated with desmosomes.|
|Tissue Location||Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Yarden, R.I., et al. Mol. Carcinog. 49(6):545-555(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Beaudry, V.G., et al. Am. J. Med. Genet. A 149A (9), 1952-1957 (2009) :
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