PERP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q96FX8 |
Other Accession | NP_071404.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 21386 Da |
Antigen Region | 162-191 aa |
Gene ID | 64065 |
---|---|
Other Names | p53 apoptosis effector related to PMP-22, Keratinocyte-associated protein 1, KCP-1, P53-induced protein PIGPC1, Transmembrane protein THW, PERP, KCP1, KRTCAP1, PIGPC1, THW |
Target/Specificity | This PERP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the C-terminal region of human PERP. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PERP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PERP |
---|---|
Function | Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. |
Cellular Location | Cell junction, desmosome {ECO:0000250|UniProtKB:Q9JK95}. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316). {ECO:0000250|UniProtKB:Q9JK95, ECO:0000269|PubMed:31898316} |
Tissue Location | Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Yarden, R.I., et al. Mol. Carcinog. 49(6):545-555(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Beaudry, V.G., et al. Am. J. Med. Genet. A 149A (9), 1952-1957 (2009) :
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