|Application ||WB, E|
|Other Accession||Q9D287, Q5RKQ0, NP_005863.1|
|Calculated MW||26131 Da|
|Antigen Region||21-49 aa|
|Other Names||Pre-mRNA-splicing factor SPF27, Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Spliceosome-associated protein SPF 27, BCAS2, DAM1|
|Target/Specificity||This BCAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human BCAS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCAS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
BCAS2 is involved in mRNA splicing (By similarity).
Kuo, P.C., et al. Cancer Res. 69(23):8877-8885(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Qi, C., et al. Biochem. Biophys. Res. Commun. 328(2):393-398(2005)
Lee, S., et al. Cancer Lett. 188 (1-2), 121-126 (2002) :
Maass, N., et al. Cancer Lett. 185(2):219-223(2002)
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