|Application ||WB, E|
|Other Accession||Q9JJH3, O54897, NP_061844.1|
|Calculated MW||39818 Da|
|Antigen Region||193-221 aa|
|Other Names||Probable G-protein coupled receptor 27, Super conserved receptor expressed in brain 1, GPR27, SREB1|
|Target/Specificity||This GPR27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-221 amino acids from the Central region of human GPR27.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR27 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. Possible candidate for amine-like G- protein coupled receptor.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum|
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Provided below are standard protocols that you may find useful for product applications.
GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM].
Matsumoto, M., et al. Biochem. Biophys. Res. Commun. 272(2):576-582(2000)
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