|Application ||WB, IHC-P, E|
|Other Accession||NP_005146.3, NP_619731.1|
|Calculated MW||34225 Da|
|Antigen Region||183-212 aa|
|Other Names||Lysosomal thioesterase PPT2, PPT-2, 312-, S-thioesterase G14, PPT2|
|Target/Specificity||This PPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.|
|Tissue Location||Broadly expressed, with highest levels in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Three transcript variants encoding different isoforms have been described for this gene, with one of the isoforms being inactive. [provided by RefSeq].
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
McKinnon, E., et al. Diabetes Obes Metab 11 SUPPL 1, 92-100 (2009) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
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