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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTPRN Antibody (Center)   

PTPRN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PTPRN Antibody (Center) AP14523c
    PTPRN Antibody (Center) (Cat. #AP14523c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PTPRN antibody detected the PTPRN protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16849
Other Accession NP_002837.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 105848 Da
Antigen Region 288-316 aa
Additional Information
Gene ID 5798
Other Names Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
Target/Specificity This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTPRN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ICA3, ICA512
Function Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
Cellular Location Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules
Tissue Location Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.


Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :
Honeyman, M.C., et al. J. Immunol. 184(4):2204-2210(2010)
Weenink, S.M., et al. J. Autoimmun. 33(2):147-154(2009)
Burbelo, P.D., et al. Diabetes Care 31(9):1824-1826(2008)
Williams, A.J., et al. Diabetologia 51(8):1444-1448(2008)

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$ 295.00
$ 99.00
Cat# AP14523c
(40 western blots)
Availability: In Stock
Bulk Size
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