|Application ||WB, E|
|Calculated MW||105848 Da|
|Antigen Region||288-316 aa|
|Other Names||Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512|
|Target/Specificity||This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPRN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules|
|Tissue Location||Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :
Honeyman, M.C., et al. J. Immunol. 184(4):2204-2210(2010)
Weenink, S.M., et al. J. Autoimmun. 33(2):147-154(2009)
Burbelo, P.D., et al. Diabetes Care 31(9):1824-1826(2008)
Williams, A.J., et al. Diabetologia 51(8):1444-1448(2008)
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