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SFTPA1B Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Country
United States
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Ordering Information
Catalog # Size Availability Price  
AP14524c 0.1 mg 400 ul In Stock $ 255.00 Add to cart
AP14524c-ev20 20 ug 100 ul In Stock $ 95.00 Add to cart
  • Specification
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SFTPA1B Antibody (Center) - Product info

ApplicationWB, IHC
  • Applications Legend:
  • W=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • F=Flow Cytometry
Primary AccessionQ8IWL2
Other AccessionQ8IWL1, NP_001087239.2, NP_005402.3
ReactivityHuman
Concentration0.25 mg/ml
IsotypeRabbit Ig
Calculated MW26242 Da

SFTPA1B Antibody (Center) - Additional info

Gene ID 653509
Other Names
SFTPA1; COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B; Pulmonary surfactant-associated protein A1; 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4
Target/Specificity
This SFTPA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human SFTPA1B.
Dilution
WB~~1:100~500
IHC~~1:10~50
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
SFTPA1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.

SFTPA1B Antibody (Center) - Protein Information

Name SFTPA1
Synonyms COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
Function
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration
Cellular Location
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film

SFTPA1B Antibody (Center) - Related products

AP14524c: SFTPA1B Antibody (Center)

SFTPA1B Antibody (Center) - Application data

  • SFTPA1B Antibody (Center) (Cat. #AP14524c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SFTPA1B antibody detected the SFTPA1B protein (arrow).

  • SFTPA1B Antibody (Center) (AP14524c)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung adenocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SFTPA1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

SFTPA1B Antibody (Center) - Research Areas

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BACKGROUND

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants.

REFERENCES

Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) : Liu, D.Y., et al. Zhongguo Dang Dai Er Ke Za Zhi 12(6):444-446(2010) Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010) Berg, T., et al. Biochim. Biophys. Acta 1543(1):159-173(2000) Childs, R.A., et al. J. Biol. Chem. 267(14):9972-9979(1992)