|Application ||WB, E|
|Calculated MW||78806 Da|
|Antigen Region||663-692 aa|
|Other Names||Solute carrier family 15 member 1, Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, Peptide transporter 1, SLC15A1, PEPT1|
|Target/Specificity||This SLC15A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-692 amino acids from the C-terminal region of human SLC15A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC15A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.
Dalmasso, G., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G687-G696 (2010) :
Pieri, M., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (1), G136-G143 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Geissler, S., et al. J. Agric. Food Chem. 58(4):2543-2547(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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