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SLC15A1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P46059 |
| Other Accession | NP_005064.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 78806 Da |
| Antigen Region | 663-692 aa |
| Gene ID | 6564 |
|---|---|
| Other Names | Solute carrier family 15 member 1, Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, Peptide transporter 1, SLC15A1, PEPT1 |
| Target/Specificity | This SLC15A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-692 amino acids from the C-terminal region of human SLC15A1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC15A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC15A1 (HGNC:10920) |
|---|---|
| Function | Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (PubMed:7896779, PubMed:9835627, PubMed:8914574, PubMed:15521010, PubMed:18367661, PubMed:19685173, PubMed:26320580) (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed:9835627, PubMed:15521010). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical membrane of enterocytes |
| Tissue Location | Expressed in small intestine. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.
References
Dalmasso, G., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (3), G687-G696 (2010) :
Pieri, M., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (1), G136-G143 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Geissler, S., et al. J. Agric. Food Chem. 58(4):2543-2547(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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