|Application ||WB, E|
|Calculated MW||24682 Da|
|Antigen Region||176-205 aa|
|Other Names||26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, PSMD9|
|Target/Specificity||This PSMD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-205 amino acids from the C-terminal region of human PSMD9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSMD9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.|
|Tissue Location||Expressed in all tissues tested, highly expressed in liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.
Gragnoli, C. J. Cell. Physiol. 223(1):1-5(2010)
Huang, L.W., et al. Pathol. Oncol. Res. 16(1):81-86(2010)
Gragnoli, C. J. Cell. Physiol. 222(2):265-267(2010)
Kaneko, T., et al. Cell 137(5):914-925(2009)
Kim, J., et al. Clin. Cancer Res. 15(1):81-90(2009)
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