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PSMD9 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PSMD9 Antibody (C-term) AP14537B
    PSMD9 Antibody (C-term) (Cat. #AP14537b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PSMD9 antibody detected the PSMD9 protein (arrow).
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O00233
Other Accession NP_002804.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24682 Da
Antigen Region 176-205 aa
Additional Information
Gene ID 5715
Other Names 26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, PSMD9
Target/Specificity This PSMD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-205 amino acids from the C-terminal region of human PSMD9.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPSMD9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSMD9
Function Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
Tissue Location Expressed in all tissues tested, highly expressed in liver and kidney
Research Areas
Citations (0)
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Background

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.

References

Gragnoli, C. J. Cell. Physiol. 223(1):1-5(2010)
Huang, L.W., et al. Pathol. Oncol. Res. 16(1):81-86(2010)
Gragnoli, C. J. Cell. Physiol. 222(2):265-267(2010)
Kaneko, T., et al. Cell 137(5):914-925(2009)
Kim, J., et al. Clin. Cancer Res. 15(1):81-90(2009)

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$ 182.50
$ 70.00
Cat# AP14537B
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