|Application ||WB, E|
|Other Accession||Q8BH43, A2VDK6, NP_008921.1|
|Calculated MW||54284 Da|
|Antigen Region||162-190 aa|
|Other Names||Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2, Protein WAVE-2, Verprolin homology domain-containing protein 2, WASF2, WAVE2|
|Target/Specificity||This WASF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-190 amino acids from the Central region of human WASF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WASF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=At the interface between the lamellipodial actin meshwork and the membrane|
|Tissue Location||Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.
Takahashi, K., et al. Cell. Signal. 22(3):510-518(2010)
Lebensohn, A.M., et al. Mol. Cell 36(3):512-524(2009)
Cai, X., et al. Lung Cancer 65(3):299-305(2009)
Morimura, S., et al. Biochem. Biophys. Res. Commun. 382(3):614-619(2009)
Takahashi, K., et al. Cell. Signal. 21(5):695-703(2009)
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