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>   home   >   Products   >   Primary Antibodies   >   RPS19 Antibody (C-term)   

RPS19 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RPS19 Antibody (C-term) AP14541b
    RPS19 Antibody (C-term) (Cat. #AP14541b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RPS19 antibody detected the RPS19 protein (arrow).
  • SPECIFICATION
  • CITATIONS: 0
  • PROTOCOLS
  • BACKGROUND
Product Information
ApplicationWB, E
Primary AccessionP39019
Other AccessionP17074, Q29308, Q9CZX8, Q32PD5, NP_001013.1
ReactivityHuman
PredictedBovine, Mouse, Pig, Rat
HostRabbit
ClonalityPolyclonal
IsotypeRabbit Ig
Calculated MW16060 Da
Antigen Region105-133 aa
Additional Information
Gene ID6223
Other Names40S ribosomal protein S19, RPS19
Target/SpecificityThis RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the C-terminal region of human RPS19.
DilutionWB~~1:1000
FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
NameRPS19
Function Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
Cellular LocationNucleus. Note=Located more specifically in the nucleoli
Tissue LocationHigher level expression is seen in the colon carcinoma tissue than normal colon tissue
Citations (0)

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Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

References

Devlin, E.E., et al. Blood 116(15):2826-2835(2010)
Iadevaia, V., et al. Oncogene 29(40):5490-5499(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nishiura, H., et al. Apoptosis 15(8):966-981(2010)
Schuster, J., et al. Blood Cells Mol. Dis. 45(1):23-28(2010)

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$ 265.00
$ 95.00
Cat# AP14541b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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