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RPS19 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Price  
AP14541b 400 µl
(40 western blots)
In Stock
$ 265.00email & fax$ 251.75online
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AP14541b-ev 80 µl
(8 western blots)
In Stock
$ 95.00email & fax$ 90.25online
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RPS19 Antibody (C-term) - Product Information

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionP39019
Other AccessionP17074, Q29308, Q9CZX8, Q32PD5, NP_001013.1
ReactivityHuman
PredictedBovine, Mouse, Pig, Rat
Immunity Source (Host) Rabbit
Isotype Rabbit Ig
Calculated MW 16060 Da
Antigen Region 105-133

RPS19 Antibody (C-term) - Additional Information

Gene ID 6223
Other Names
RPS19; 40S ribosomal protein S19
Target/Specificity
This RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the C-terminal region of human RPS19.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
RPS19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.

RPS19 Antibody (C-term) - Protein Information

Name RPS19
Function
Required for pre-rRNA processing and maturation of 40S ribosomal subunits. {ECO:0000269|PubMed:16990592}.
Cellular Location
Nucleus {ECO:0000269|PubMed:12586610, ECO:0000269|PubMed:17517689}. Note=Located more specifically in the nucleoli
Tissue Location
Higher level expression is seen in the colon carcinoma tissue than normal colon tissue

RPS19 Antibody (C-term) - Related Products

AP12039c: RPS19 Antibody (Center)

BP12039c: RPS19 Antibody (Center) Blocking Peptides

BP14541b: RPS19 Antibody (C-term) Blocking Peptide

AT3713a: RPS19 Antibody (monoclonal) (M01)

RPS19 Antibody (C-term) - Research Areas

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BACKGROUND

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

REFERENCES

Devlin, E.E., et al. Blood 116(15):2826-2835(2010)
Iadevaia, V., et al. Oncogene 29(40):5490-5499(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nishiura, H., et al. Apoptosis 15(8):966-981(2010)
Schuster, J., et al. Blood Cells Mol. Dis. 45(1):23-28(2010)