|Application ||WB, E|
|Calculated MW||52131 Da|
|Antigen Region||92-121 aa|
|Other Names||Semenogelin-1, Semenogelin I, SGI, Alpha-inhibin-92, Alpha-inhibin-31, Seminal basic protein, SEMG1, SEMG|
|Target/Specificity||This SEMG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the N-terminal region of human SEMG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEMG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.|
|Tissue Location||Seminal vesicle.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely.
Mitra, A., et al. Biol. Reprod. 82(3):489-496(2010)
Yoshida, K., et al. Cell Motil. Cytoskeleton 66(2):99-108(2009)
Ahmed, S.U., et al. Cytotherapy 11(2):238-244(2009)
Edstrom, A.M., et al. J. Immunol. 181(5):3413-3421(2008)
Emami, N., et al. J. Biol. Chem. 283(28):19561-19569(2008)
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