|Application ||WB, E|
|Calculated MW||80578 Da|
|Antigen Region||639-667 aa|
|Other Names||Potassium voltage-gated channel subfamily C member 3, KSHIIID, Voltage-gated potassium channel subunit Kv33, KCNC3|
|Target/Specificity||This KCNC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-667 amino acids from the C-terminal region of human KCNC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.
Figueroa, K.P., et al. Hum. Mutat. 31(2):191-196(2010)
Waters, M.F., et al. Cerebellum 7(2):165-169(2008)
Waters, M.F., et al. Nat. Genet. 38(4):447-451(2006)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Brusco, A., et al. Arch. Neurol. 61(5):727-733(2004)
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