|Application ||WB, IHC-P, E|
|Other Accession||O42261, P81067, NP_077312.2|
|Calculated MW||52119 Da|
|Antigen Region||111-140 aa|
|Other Names||Iroquois-class homeodomain protein IRX-3, Homeodomain protein IRXB1, Iroquois homeobox protein 3, IRX3, IRXB1|
|Target/Specificity||This IRX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the N-terminal region of human IRX3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IRX3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).
Ragvin, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):775-780(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Lewis, M.T., et al. Cell Tissue Res. 296(3):549-554(1999)
Bellefroid, E.J., et al. EMBO J. 17(1):191-203(1998)
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