|Application ||WB, E|
|Calculated MW||41528 Da|
|Antigen Region||344-373 aa|
|Other Names||Wnt inhibitory factor 1, WIF-1, WIF1|
|Target/Specificity||This WIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-373 amino acids from the C-terminal region of human WIF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WIF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
Licchesi, J.D., et al. Oncogene 29(44):5923-5934(2010)
Fendri, A., et al. Cancer Invest. 28(9):896-903(2010)
Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)
Belshaw, N.J., et al. Carcinogenesis 31(6):1158-1163(2010)
Costa, V.L., et al. Epigenetics 5(4):343-351(2010)
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