|Application ||WB, E|
|Other Accession||Q64620, Q9CQR6, NP_001116841.1, NP_002712.1|
|Calculated MW||35144 Da|
|Antigen Region||264-293 aa|
|Other Names||Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6|
|Target/Specificity||This PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-293 amino acids from the C-terminal region of human PPP6C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP6C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.|
|Tissue Location||Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
Douglas, P., et al. Mol. Cell. Biol. 30(6):1368-1381(2010)
Dema, B., et al. Genes Immun. 10(7):659-661(2009)
Morales-Johansson, H., et al. PLoS ONE 4 (7), E6331 (2009) :
Mi, J., et al. PLoS ONE 4 (2), E4395 (2009) :
Stefansson, B., et al. Biochemistry 47(5):1442-1451(2008)
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