|Application ||WB, IHC-P, E|
|Other Accession||Q91614, P62168, Q8BNY6, P62167, Q2V8Y7, NP_001122298.1, NP_055101.2|
|Predicted||Bovine, Chicken, Mouse, Rat, Xenopus|
|Calculated MW||21879 Da|
|Antigen Region||1-30 aa|
|Other Names||Neuronal calcium sensor 1, NCS-1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein, NCS1, FLUP, FREQ|
|Target/Specificity||This FREQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FREQ.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FREQ Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Handley, M.T., et al. PLoS ONE 5 (5), E10534 (2010) :
Torres, K.C., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 33(2):229-234(2009)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
Kapp-Barnea, Y., et al. Mol. Biol. Cell 17(9):4130-4141(2006)
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