|Application ||WB, IHC-P, E|
|Calculated MW||24789 Da|
|Antigen Region||120-148 aa|
|Other Names||Placenta growth factor, PlGF, PGF, PGFL, PLGF|
|Target/Specificity||This PGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-148 amino acids from the Central region of human PGF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PGF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.|
|Cellular Location||Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin|
|Tissue Location||While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
The PGF gene encodes placenta growth factor, a homolog of vascular endothelial growth factor (VEGFA; MIM 192240), that selectively binds to VEGFR1 (FLT1; MIM 165070) and is involved in angiogenesis (Fischer et al., 2007 [PubMed 17981115]; Bais et al., 2010 [PubMed 20371352]).
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Cowans, N.J., et al. Prenat. Diagn. 30(6):565-570(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Andersson, M.K., et al. BMC Cancer 10, 249 (2010) :
Pan, P., et al. BMC Cell Biol. 11, 36 (2010) :
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