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TRPC3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13507 |
| Other Accession | Q9JMI9, Q9QZC1, NP_003296.1, NP_001124170.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 105538 Da |
| Antigen Region | 765-793 aa |
| Gene ID | 7222 |
|---|---|
| Other Names | Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3, TRPC3, TRP3 |
| Target/Specificity | This TRPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-793 amino acids from the C-terminal region of human TRPC3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRPC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPC3 |
|---|---|
| Synonyms | TRP3 |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:8646775, PubMed:9417057, PubMed:9930701, PubMed:20095964, PubMed:30139744, PubMed:29726814, PubMed:35051376). May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (PubMed:8646775). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Smedlund, K., et al. Circ. Res. 106(9):1479-1488(2010)
Kiyonaka, S., et al. Yakugaku Zasshi 130(3):303-311(2010)
Nishida, M., et al. Yakugaku Zasshi 130(3):295-302(2010)
Shirakawa, H., et al. Yakugaku Zasshi 130(3):281-287(2010)
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