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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRPC3 Antibody (C-term)   

TRPC3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TRPC3 Antibody (C-term) AP14579b
    TRPC3 Antibody (C-term) (Cat. #AP14579b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TRPC3 antibody detected the TRPC3 protein (arrow).
  • WB - TRPC3 Antibody (C-term) AP14579b
    Western blot analysis of TRPC3 (arrow) using rabbit polyclonal TRPC3 Antibody (C-term) (Cat. #AP14579b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TRPC3 gene.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13507
Other Accession Q9JMI9, Q9QZC1, NP_003296.1, NP_001124170.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 96009 Da
Antigen Region 765-793 aa
Additional Information
Gene ID 7222
Other Names Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3, TRPC3, TRP3
Target/Specificity This TRPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-793 amino acids from the C-terminal region of human TRPC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRPC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPC3
Synonyms TRP3
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis
Research Areas
Citations (0)

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Background

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Smedlund, K., et al. Circ. Res. 106(9):1479-1488(2010)
Kiyonaka, S., et al. Yakugaku Zasshi 130(3):303-311(2010)
Nishida, M., et al. Yakugaku Zasshi 130(3):295-302(2010)
Shirakawa, H., et al. Yakugaku Zasshi 130(3):281-287(2010)

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Cat# AP14579b
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(40 western blots)
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